lod score การใช้

• This can be accomplished by plotting a cumulative LOD score alongside the overlaid blocks of homozygosity.
• On the other hand, a LOD score less than-2.0 is considered evidence to exclude linkage.
• The study confirmed the Xq28 linkage to homosexuality by two-point and multipoint ( MERLIN ) LOD score mapping.
• The data strongly replicated Hamer?s Xq28 findings as determined by both two-point and multipoint ( MERLIN ) LOD score mapping.
• If one block of homozygosity is a result of a very non-diverse region of the genome, the LOD score will be very low ).
• A LOD score of 3 translates to a " p "-value of approximately 0.05, and no multiple testing correction ( e . g.
• :I ran across but for some reason I'm having trouble finding a good simple Web-based site for this sort of calculation ( see LOD score ).
• By convention, a LOD score greater than 3.0 is considered evidence for linkage, as it indicates 1000 to 1 odds that the linkage being observed did not occur by chance.
• Still, a good program could maximize the LOD scores for a more precise result, and give a better idea of the confidence of the mapping . talk ) 23 : 21, 26 March 2011 ( UTC)
• Although it is very unlikely that a LOD score of 3 would be obtained from a single pedigree, the mathematical properties of the test allow data from a number of pedigrees to be combined by summing their LOD scores.
• Although it is very unlikely that a LOD score of 3 would be obtained from a single pedigree, the mathematical properties of the test allow data from a number of pedigrees to be combined by summing their LOD scores.
• The study population included 409 independent pairs of gay brothers, who were analyzed with over 300, 000 single-nucleotide polymorphism markers, and confirmed the Xq28 linkage by two-point and multipoint ( MERLIN ) LOD score mapping.
• The method makes use of a genetic map of the typed markers, and, like analysis of variance, assumes the presence of a single QTL . In interval mapping, each locus is considered one at a time and the logarithm of the odds ratio ( LOD score ) is calculated for the model that the given locus is a true QTL . The odds ratio is related to the Pearson correlation coefficient between the phenotype and the marker genotype for each individual in the experimental cross.
• Brzustowicz and others, in collaboration with Dr . Anne Bassett at the University of Toronto, have conducted a genome-wide genetic linkage study of schizophrenia with a set of moderately large extended families from eastern Canada, and have identified " a major schizophrenia susceptibility locus on chromosome 1q21-22 with a multipoint lod score of 6.50 ( p < 0.0002 ) . " Using the Positive and Negative Syndrome Scale ( PANSS ), they have also detected a significant linkage of the severity of positive symptoms of schizophrenia to chromosome 6.